Ongoing Research Projects
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Medications and microbiome in microscopic colitis
To study the relationship between medications, the gut microbiome, and risk of microscopic colitis in older adults, we will investigate three major goals. First, we will identify pharmacologic determinants of MC, leveraging a nationwide cohort of all MC patients (n~14,000) in Sweden to identify medications associated with risk of the disease. Second, we will characterize compositional and temporal changes in the gut microbiota related to disease activity in MC (n = 200) and identify microbial signatures of MC among older adults with chronic diarrhea (n = 400) in our prospective colonoscopy-based cohort using metagenomic sequencing. Third, we will identify the microbial and metabolite mediators of the association between medications and risk of MC.
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